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Idaho Hormones

A field station for the long signal

Reading list

The CJC-1295 shelf

A hormone trace, a growth result and a protein profile each earn a space on this shelf.

Design and hormone measurements

The albumin-bioconjugate paper follows the design into rat and laboratory experiments. The healthy-adult duration study supplies the prolonged GH and IGF-1 measurements. The pulse study in healthy men then examines the secretion pattern under sustained stimulation.

I pair the duration paper with the pulse paper. Seeing the two together makes the long signal more interesting than either a single concentration or the long-acting description alone.

Growth, protein profiles and identification

The GHRH-knockout mouse study changes the outcome to body weight and length. The serum-protein study in healthy young adult men looks for biological traces of GH/IGF-1-axis activation. The analytical-identification paper establishes the identity of CJC-1295 in an unknown preparation.

For broader context, the review of GHRH and its analogues discusses receptor signaling, long-acting design and the therapeutic and investigational landscape. That breadth helps place the individual experiments in context. The direct CJC-1295 findings still come from the experiments themselves.

  1. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog ↗
  2. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults ↗
  3. Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog ↗
  4. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse ↗
  5. Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects ↗
  6. Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation ↗
  7. Growth hormone-releasing hormone and its analogues in health and disease ↗